You should also look at various web sites and organizations supporting a renewed commitment to the 10th Amendment. The discussion on those sites is compelling. Start with http://www.tenthamendmentcenter.com/.
The 10th amendment has often been cited as a basis to challenge Obamacare, but given the vast expansion of the Commerce Clause and even something called the "Dormant Commerce Clause" and the "Necessary and Proper" clause, Supreme Court precedent is not favorable.
Simply renewing a commitment to or better enforcing the 10th amendment will take too long since the courts are so overly dominated by progressives/liberals. I also fear it wouldn't be a lasting solution since it would require the constant, active drive of the people to maintain it. People and generations can be prone to be lazy, and an amendment might help to protect the country in those times.