Look up “protein domains” and “cumulative selection” to find out why the model used to calculate the probability is wrong.
From a Stastistics textbook ….
“The number of permutations of N objects is N!” That is … 1x2x3x4x5x … x N.
“The total number of possible selections of r objects from N distinct objects is called the number of combinations of N objects taken r at a time and will be called C(N,r)”; and C(N,r) = N!/(r!(N-r)!)
. Given Jones’ standing in scientific circles, I’d say that he's right. Ref ... http://www.youtube.com/watch?v=liR5aGC9pn0