You just have to One: see it coming. Two: figure out it’s course and speed. And Three: put something in its path before it gets there.
At some point the amount of time and money one invests in making a sophisticated hyper-sonic weapon system exceedes that required to make unsophisticated kill devices that accomplishes one through three.
Deploying a few million ball bearings within a "probability cloud" of a sufficient diameter to encompass the max load factor (probably less than 10g) limited path of the vehicle.