He might make a comment about Islam but he would not insult them in such a demeaning fashion. They really would then try to kill him.
I don't think Larry David has the guts to even mention the Koran in one of his shows. It takes no courage to piss on Christ, because Christians may be offended, but they won't kill you and your family and the horse you rode in on.
But publicly ridicule Islam or criticize Mohammed and you risk death from a billion directions.