The Downing of TWA Flight 800 (July 17, 1996)
On September 25, 1978, PSA Flight 182, a Boeing 727-200, crashed in San Diego while trying to land at Lindbergh Field (San Diego International Airport), California after a Cessna 172 operated by Gibbs Flite Center encroached the flight path. The 727 crashed at the intersection of Dwight and Nile. The Cessna fell a few blocks away. All 135 on board the PSA were killed as well as the two on the Cessna, and 7 on the ground. At the time, it was the worst plane crash in the United States.
And as much as you want to believe, PSA Flight 182 wasn't brought down by a missile either.