The reason it is so hard to get rid of fat is that for the vast majority of the time humans have been on Earth, “fat was life”. If you lost too much fat you would die. So the body has all sorts of mechanisms to create and protect its fat.
Fat is also an important part of the immune system. Within fat are clumps of cells called MAST cells, that when signaled or irritated produce chemicals important to the immune response against disease. The more fat you have, the more MAST cells you have, and more than proportionally. So a fat person has far more than a skinny person.
In turn, when MAST cells are irritated, some of the chemicals they release are “pro-fat”, making it easier to gain and keep fat.
Within the last month, researchers have discovered that if a fat mouse is returned to a normal diet, but given MAST-inhibitor chemicals, they quickly lose weight until normal weight.
MAST inhibitors are also sold OTC in drug stores, for two other purposes. As nasal spray and eye drops. Unfortunately, these only subdue local MAST cells, not those in the body, and they are not well absorbed in the digestive tract. So even if you drank a whole bunch, it probably wouldn’t do much.
However, otherwise this stuff is very safe and effective. And this is why there is going to be a rush of other fat-loss products, that may be far less effective. If they don’t sell them soon, nobody will want them because they can buy a drug that works.
You seem to know lots about this subject — are you saying that these mast cell inhibitors only work via injection?
And that, there would be no easy cheap OTC pill-form of mast inhibitor anytime in the near future?
Also, does the anti-histamine Benadryl have any inhibatory impact upon mast cells?
Thanks.