It is possible that with Portman, Toomey, and a strange twist with the FL seat, that we could replace three RINOs/former RINO (in Sphincter's case) with three conservatives and only pick up one seat in the process, yet have many more conservatives. Boxer is very low in her polls, too, and has a very well funded opponent.
Don’t forget Connecticut Dodd looks so dead that the GOP primary has attracted 4 maybe 5 contenders, and that might be going to 6. Seems there are a lot of bored people with money in Connecticut (like Linda McMahon of the WWE wrestlin)