A current paradigm states that monocytes circulate freely and patrol blood vessels but differentiate irreversibly into dendritic cells (DCs) or macrophages upon tissue entry. Here we show that bona fide undifferentiated monocytes reside in the spleen and outnumber their equivalents in circulation.
This is a study published last month, not 30 years ago.
I could publish an article tomorrow proving that the earth was round, but that wouldn’t make it new. Point is that clinicians have known about the downside of splenectomy for many, many years. Look it up.