A mouse needs 5 cups a day. So a human would need the caffeine in several thousand cups.
40 cups in a short period can be lethal. 1000 would kill you. Those mice must have been wired or dead!
The lab animals were given what would be the EQUIVALENT of giving humans 5 cups of coffee.
One thing that researchers and commentators forget to mention is that there is great variation in the amount of caffeine in different roasts of coffee, and also in different preparations.
For instance, expresso is brewed so quickly, that although it tastes very strong, it's not very high in caffeine.
Likewise, heat can destroy caffeine, so a dark french roast, so popular today, has less caffeine to it's equivalent cup of breakfast coffee brewed decades ago.
For many years it has been known that the incidence of both Parkinson's Disease and the various dementias, including Alzheimer's has been greater in NON-coffee drinkers, but they've never been able to explain why.
I hope to hear more news about human trials they are setting up with Alzheimer's patients and caffeine.