Healthy mice. OK.
Perhaps I should inject my Zaditor eye drops.
Ping for later
My husband (type 2 diabetic) has been having terrible allergy/drainage problems lately. I want him to read this, thanks for the ping.
....Mast cells are immune cells that facilitate healing in wounded tissue by increasing blood flow to the site. In certain conditions, however, mast cells build up to levels far beyond what the body needs. When this happens, these cells become unstable and eventually, like punctured trash bags, leak molecular "garbage" into the tissue. This results in chronic inflammation that can cause asthma and certain allergies.
As Shi and postdoctoral research fellow Jian Liu discovered, mast cells were far more abundant in fat tissue of obese and diabetic humans and mice than they were in fat tissue from individuals of normal weight. This led to the obvious question, by regulating mast cells, could we then control the obesity and diabetic symptoms?...
....The mice were divided into four groups. The first was the control group. The second group was simply switched to a healthy diet. The third was given cromolyn or Zaditor. And the fourth group was given the drug and switched to a healthy diet.
While symptoms of the second “healthy diet” group improved moderately, the third “allergy medicine” group demonstrated dramatic improvements in both body weight and diabetes. The fourth group exhibited nearly 100 percent recovery in all areas.
Ping for later
The newer Claritin type allergy drugs do not suppress appetite so much.
I suppose if you could trigger an allergy to most foods that would tend to fight obesity....
Some clarity about Mast cells.
“A mast cell (or mastocyte) is a resident cell of several types of tissues and contains many granules rich in histamine and heparin. Although best known for their role in allergy and anaphylaxis, mast cells play an important protective role as well, being intimately involved in wound healing and defense against pathogens.”
Mast cells are part of the bodies fat, and the more fat you have, the more mast cells you have. However, when mast cells are irritated, they release histamines into the body. Think of a mild allergic reaction.
This irritation tend to aggravate immune system disorders like diabetes and arthritis, and a bunch of others. And the irritation tends to prolong the irritation of the mast cells. Irritated mast cells irritate themselves.
Plus, importantly, irritated mast cells tell the body to store more fat.
So rheumatologists are now advising their patients to lose weight, because this will reduce the number of mast cells, and thus the irritation to their arthritis.
But this is kind of putting the cart before the horse, because it will be extra hard to lose weight with irritated mast cells.
This is where these drugs come in to play. They are antihistamines for the mast cells. They soothe the mast cells, so they stop dumping histamines. And your body, instead of trying to put on more weight, realizes it is overweight, and tries to shed pounds and return to a more normal weight.
Importantly, the scientists didn’t say *how much* of these drugs was needed for the effect.
But assuming they are about the same strength, the Zaditor’s active ingredient, Ketotifen, is .025% strength, which is equivalent to ketotifen fumarate at .035%.
NasalCrom (I couldn’t help but laugh. The preferred nasal spray of barbarians). Cromolyn sodium, at 40 milligrams per milliliter.
But before you run right out and chug-a-lug either of these drugs, it is important to note:
“Cromolyn sodium is poorly absorbed from the gastrointestinal tract. After instillation of cromolyn sodium nasal solution, less than 7% of the total dose administered is absorbed and is rapidly excreted unchanged in the bile and urine. The remainder of the dose is expelled from the nose, or swallowed and excreted via the alimentary tract.”
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OK im taking this to my doctor and finding out what he can do for me ill be a test pig if it will help me get rid of my type 2 and a little weight its worth a shot ...
Ping
bttt
What a bunch of crap!
The immunology of diabetes has been a subject of intense interest since I enrolled in medical school in 1972, and before.