With the WV GOP in the total disaray it's in now (and has been for a while) I don't see how that could happen. Rockefeller just won and if Byrd goes before the end of his term four years from now, Manchin will appoint a Rat. (Anne Barth?)
The voters should realize that voting for a Republican presidential nominee and Dem senators is at cross purposes. Every southern state got away from that except Arkansas, and I think WV will in the next election cycle or two. If Obama and Dem policies damage the coal industry, that might happen even faster.