Unless the Cabinet determines that he is unable to perform his duties.
That would be a creative, one might even say "Hollywoody" reading of the 25th, considering that in this instance, the President wasn't dead or injured. And, considering the impetus of the 25th, the Kennedy assassination, I'm not sure it would be in keeping with the spirit or intent of the 25th.
That would be the stuff of a real Constitutional crisis. Is a legal disability what the Amendment was passed to address. That would be a question for SCOTUS.