Yes, it certainly does. Look at most of the truly great musicians---Hendrix, Morrison, Joplin, Elvis, Bonham---who died of drugs or the many great comedians who died of obesity, such as Candy and Farley, or depression, Rich Jenni.
As a writer and former musician, it's almost like creating extracts a toll from your soul. Think of how many musicians or comedians we say "used to be great," or "used to be funny." Look at Boz Scaggs, who had one album containing 3-4 truly timeless knockout songs, and never put together another solid album or Brett Easton Ellis who never could get another "Less Than Zero."
Oddly enough Glenn Gould, the great classical pianist, also died at the age of 50 and supposedly form a life long addiction to pain killers. It seems to permeate all levels of society: from the King of Pop, to the King of Rock & Roll, to a King of Classical Music. I remember Boz’s first album — Low Down, etc. -- it was truly great!