I know exactly what you mean. People should try Hoodia, if you can find a legit one. H57 is good, CVS also has one that works. I started with Hoodia which simply crushes hunger using a cactus extract and green tea compound (EGCG). Once I had cut down the size of meals and calories, I phased out Hoodia and my stomach had adjusted to the new regimen. the hunger was far less, and I was able to keep myself feeling full with high fiber stuff (beans, grains, oatmeal, etc).
Tried Hoodia. Didn't work.