She has been a vocal opposer of Proposition 8 in California. Her oppositon may be characterized as "militant."
From a New York Times November 15, 2008 article:
In Las Vegas, the comedian Wanda Sykes surprised a crowd of more than 1,000 rallying outside a gay community center by announcing that she is gay and had wed her wife in California on Oct. 25. Ms. Sykes, who divorced her husband of seven years in 1998, had never publicly discussed her sexual orientation but said the passage of Proposition 8 had propelled her to be open about it.
"I felt like I was being attacked, personally attacked — our community was attacked," she told the crowd.
Well Wanda is just too ugly to be a hetero...