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To: neverdem; Brad's Gramma

Plavix - probably not bad advice. It works on platelets through a different mechanism.

Warfarin - BAD advice. 10 minutes in the penalty box for unlicensed practice of medicine. Warfarin works on the Vitamin-K dependent clotting factors (II, VII, IX, and X) in the blood plasma, not on the platelets. No evidence whatsoever that it prevents heart attacks.

In case you were considering Heparin or it’s low-molecular analogs, they act on plasma antithrombin through its inhibition for factor Xa. So that doesn’t work well either.


32 posted on 05/04/2009 4:33:32 AM PDT by CholeraJoe (Saiga 12 shotgun - When the Zombies see it, they'll sh*t bricks.)
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To: CholeraJoe; Brad's Gramma
Warfarin - BAD advice. 10 minutes in the penalty box for unlicensed practice of medicine.

I have a license. It was my second choice at 4 AM.

Warfarin works on the Vitamin-K dependent clotting factors (II, VII, IX, and X) in the blood plasma, not on the platelets. No evidence whatsoever that it prevents heart attacks.

Warfarin sodium, aka coumadin, is another drug that inhibits the formation of blood clots, i.e. anticoagulation. Unlike aspirin, you can't get it over the counter. Since it works on the Vitamin-K dependent clotting factors, it is very sensitive to diet. A doc prescribing it will require frequent blood testing.

In case you were considering Heparin or it’s low-molecular analogs, they act on plasma antithrombin through its inhibition for factor Xa. So that doesn’t work well either.

Heparin or it’s low-molecular analogs require daily injections.

"That study evaluated the risks and benefits of aspirin in the primary prevention of heart disease in almost 40,000 women. It reported a 23% reduction in the risk of ischemic stroke with aspirin use, but no significant benefit for heart attack."

Primary prevention reduces the risk of the first morbid event, in this case either ischemic stroke, aka ischemic cerebrovascular accident(CVA) or "heart attack," aka myocardial infarction. Persantine, aka dipyridamole, and Ticlid, aka ticlopidine, are other prescription, oral antiplatelet drugs.

Besides aspirin, I don't know if they have data supporting these other drugs used for the primary prevention of CVAs or myocardial infarctions. All of them increase the risk of bleeding complications such as ulcers and hemorrhagic CVAs. Hemorrhagic CVAs cause about ten to fifteen percent of strokes, but they tend to have a worse prognosis for those who survive them as opposed to ischemic CVAs which account for about eighty percent of strokes.

36 posted on 05/04/2009 11:42:08 AM PDT by neverdem (Xin loi minh oi)
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