Ewwwwweeeeee...!
Don't get real personal with Frank, simply bring up the fact that one of his gay lovers ran a prostitution ring out of Frank's home.
Then bring up the fact that another gay lover, of Franks, worked for Freddie Mac? (I believe) and helped CAUSE this mortgage mess, while making huge sums of money for himself.
Attack Frank hard, with a good candidate.
Even if that candidate does not win, that candidate will recruit thousands of ACTIVE conservatives to the Mass. GOP.
Then?
Take over your Party with that grass roots base of support!