Actually, there has. And done in a lab. Scientists (you know, those evil fellows that keep trying to do SCIENCE, instead of RELIGION) have bred fruit flies to the point where a separated population is no longer fertile with a different population of fruit fly, which is precisely what "a new species" is. This means that those two populations are less kin to each other than lions and tigers (for example), which can cross-breed to produce hybrids.
Do you approve of science creating infertle humans where evil people decide what person is allowed to bring a child into this world?