if it hadn’t worked for the off-label indications (what are the agents that have FDA approval for these symptoms?), they never would have made billions on it.
They’ve made billions because they spend millions on marketing, not because they actually work. Most studies show, for example, that antidepressants work about as often as placebos, but because pharmaceutical companies don’t have to publish all their drug trials, they pick a couple good ones and have their reps spout sunshine and lollipops while they buy the doctors lunch.