There’s a lot of misses with that range but there’s always that one hit per five or six rounds. The point is, with a full magazine or cylinder, a person should try to take the shot at the closest range possible. If that range is a hundred yards so be it. It’s still worth the effort to try to stop a madman.
I have a friend who taught me about long range shooting with a handgun. I fine tuned his techique to include some ridiculously long ranges. My son bought me a laser range finder for Christmas last year so the ranges are authentic.
I found the easiest way to shoot at distance is to use both eyes. It’s very important to keep the sights aligned so you do that with your shooting eye. The other eye is to have a double vision so you can check your elevation.
Also helps if you are very strong side eye dominant (for me anyway). I usually can keep both eyes open even while using a rifle scope.
Got a nice deer that way, saw it out of my “bad” eye, and realized the head gear was bigger than the spike I was looking at with the good eye.