Nope. More small states vote GOP and more large states vote Democrat. In normal years.
The GOP usually has a slight but potentially important built-in electoral college advantage. For example, it made the difference in Bush v. Gore.
With the Electoral College system, the states of Alaska, Wyoming, N and S Dakota and Montana, have a total of 15 votes, more than 2.7% of the total.
With a popular vote, these states would have 1.17% of the vote, considerably less than half of their present influence.
I think the question of whether an interstate compact, as proposed by Mr. Soros, is constitutional is quite open. In any case, such a compact could not be legal unless approved by Congress, and could presumably be invalidated by any future Congress by majority vote.
The Republican Party faces a demographic shift in the nation that will be very difficult to overcome. Primarily Texas, a state that by 2024 if not 2020 will not be a battleground state but instead a Democratic state.
And without Texas, the GOP has no chance to win a national election with the current EC system.