That kind of disinformation is cruel! - The opposite has been proven, but the Pharma monsters keep fighting back for the dollars.
At least with the pharmaceutical brands you know what you are getting.ie. with one gram of Premarin Cream it is .625 grams of conjugated estrogens. They have been studied for sixty plus years—how much estrogen is in a given compounded cream? Where did the estrogen come from-a plant? then it had to be synthesized. Urine from a mare is as natural as a plant. No synthesizing. Studied more than any other drug.
When you smear the cream on your vulva how much do you use? How much is absorbed? It may not have a “first pass” on the liver but it will pass eventually thru the liver. If it is a lotion is it a suspension of equal distribution top to bottom? Meaning is the first pump the same strength as the last thirty days later? So many questions and no answers. Would you take a bio-identical oral contraceptive? Not me.