Indiana is a special case.
The big issue there was ethanol subsidies, and McCain’s opposition to them.
I believe Bush failed to explain to the American people in clear,compelling terms why we invaded Iraq.Bush angered conservatives by lax immigration policies.Bush's Homeland Security Department and its policies angered everybody. McCain's comment that we might have troops in Iraq for many years was not popular. Sadly,the nation's farmers care more about crop subsidies than anything else;American agriculture has been socialized since FDR.And most of the farmers seem to love it. Union workers also blame Republicans for factory jobs lost ,even though NAFTA was truly a non-partisan act.(of economic suicide).
McCain foolishly limited his own campaign with the MCCain-Feingold program.MCCain insisted on playing nice ,yet was villified as running a negative campaign.