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Harvard U. Scientists Create Safer Stem Cells
cbsnews.com ^ | Sep 30, 2008 | June Q. Wu

Posted on 10/02/2008 5:20:19 PM PDT by neverdem

(UWIRE.com) This story was written by June Q. Wu, Harvard Crimson

Researchers at the Harvard Stem Cell Institute are one step closer to achieving the ultimate promise of stem cell research creating tissues for every part of the body without the use of harmful viruses or cancer-causing genes.

Harvard Medical School professor Konrad A. Hochedlinger and his colleagues reported last week on the Web site of the journal Science that they have created mouse induced pluripotent stem cells without permanently altering the genetic makeup of the cells.

Their technique allows scientists to genetically manipulate a patients cells typically skin cells or blood cells and reprogram them into a pluripotent state. Like embryonic stem cells, these cells are then capable of morphing into any type of body tissue.

Hochedlingers team inserted genes needed for cellular reprogramming with harmless adenoviruses.

Unlike retroviruses, which scientists have been using to createpluripotent cells, these viruses effectively disappear after a few cell divisions and do not integrate into the cells DNA. The effect of this is that adenoviruses are free from the chief adverse effect of genetic manipulation, which can turn on cancer genes and trigger malignant tumor growth.

The beauty of this is that if you want to use the cells therapeutically if you want to put them in somebody. It basically gets rid of the dangerous transcription factors that were used in the initial integration, said Gordon C. Weir, a Medical School professor who heads the diabetes program at the Stem Cell Institute. The last thing you want is to transplant a potentially malignant cell into a patient.

The findings have implications for creating body tissues safe to transplant into patients to treat diseases.

The next step, according to lead author Matthias Stadtfeld, is to increase the efficiency of creating pluripotent mouse cells and then try to reproduce the work in human cells.

Currently, the number of pluripotent cells produced using retroviruses is significantly higher than that from the harmless adenoviruses. Stadtfeld, who is a post-doctoral research fellow at Harvard-affiliated Mass. General Hospital, estimated that using the more dangerous retroviruses is 10 to 100 times more efficient than the new adenovirus method.

The recent advance in stem cell research is the latest in a stream of developments by Harvard researchers this past year.

At the third annual Stem Cell Summit held at the Medical School last week, University President Drew G. Faust cited four papers published this summer as evidence of the progress made at a time when federal funding for embryonic research has been constrained by a 2001 order by President Bush.

Among the discoveries were the creation of 10 disease-specific stem cell lines and the direct conversion of mouse pancreatic cells into insulin-producing beta cells that can be used to treat patients with Type I diabetes.

At a time when the promise of biomedical research has never been greater, our nation risks sending a signal to our best and brightest young researchers that the funds wont be there to support their hugely important career pursuits, Faust said in her welcoming remarks.

And though the next President may prove friendlier to stem cell research, funding for the National Institutes of Health has been frozen in recent years, meaning that it has declined in real terms.

Though he used money from the NIH New Innovator Award that he won last year, Hochedlingers research was not subject to federal embryonic stem cell restrictions because the cells were created from skin cells or blood cells instead of from embryos. His work was also funded in part by the Harvard Stem Cell Insttute.

While embryonic stem cell research has come under fire from those who consider it unethical, Harvard scientists involved in the work continue to say that the research is essential.

As long as we dont know that iPS cells are really as good as embryonic stem cells in generating all types of body tissues, we should be obliged to continue, Stadtfeld said. iPS stands for induced pluripotent stem.

Scientists are now able to generate iPS cells which are embraced by those who oppose embryonic stem cell research only because of previous work performed with embryonic stem cells, Stadtfeld said.

Copyright © 2008 Harvard Crimson via UWire


TOPICS: Culture/Society; News/Current Events; Technical
KEYWORDS: adultstemcells; ipsc; regenerativemedicine; stemcells
Induced Pluripotent Stem Cells Generated Without Viral Integration
1 posted on 10/02/2008 5:20:21 PM PDT by neverdem
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To: neverdem

Awesome. This is the future. Culturing someone’s own cells for therepy, transplant....who knows.


2 posted on 10/02/2008 5:23:13 PM PDT by allmendream (Sa-RAH! Sa-RAH! Sa-RAH! RAH RAH RAH! McCain/Palin2008)
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To: neverdem

This is great!

I’m still waiting for Jocelyn Elder’s safer bullets.


3 posted on 10/02/2008 5:45:30 PM PDT by Islander7 ("Common sense and common decency are uncommon virtues among America's left.")
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To: neverdem
I am watching "The Nature of Things" on CBC. The topic is Longevity. There was a doctor who is using a patient's own stem cells to reginerate her own jaw bone.

Embryonic stem cells are a dead end. My daughter did a research paper this summer on stem cells and she showed me the studies that are proving adult stem cells are superior to embryonic. They are getting better results with adult stem cells. Liberals keep pushing for embryonic stem cell research because they insist on human sacrifice.

4 posted on 10/02/2008 5:50:39 PM PDT by FrdmLvr ("Stand up, Chuck!")
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To: El Gato; Ernest_at_the_Beach; Robert A. Cook, PE; lepton; LadyDoc; jb6; tiamat; PGalt; Dianna; ...
Colonial clue to the rise of HIV

Study: Makeup Contains Chemicals Harmful, Cancerous to Teens

5 posted on 10/02/2008 6:33:08 PM PDT by neverdem (I'm praying for a Divine Intervention.)
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To: allmendream

The basic article heading this post is an impassioned defense of embryonic stem cell research, complaining about Pres. Bush’s prohibition on federal funding for embryonic stem cell research, and expressing hope that the next president will reverse that policy; all the while declining, of course, to note that private entities are free to invest as much as they wish in embryonic stem cell research or to question why private entities seem so hesitant to do so.


6 posted on 10/02/2008 7:29:19 PM PDT by Elsiejay
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