“Epigenetic mechanisms constrain expression by adapting regions of the genome to maintain either gene silencing or gene activity.”
Nothing about mutation, or mutation being “constrained”. EXPRESSION is being constrained. You do know what expression is don't you? It is the DNA gene being transcribed into RNA and then being translated into a protein. THAT is gene expression, and it is controlled by epigenetic mechanisms.
NOTHING about epigenetic mechanisms of DNA methylation and histone modification constrain mutation. Once again you simply have no idea what your talking about.
You do not understand the clear meaning of words. “Epigenetic mechanisms constrain expression by adapting regions of the genome to maintain either gene silencing or gene activity.” means *all* gene activity *including* mutation.
"NOTHING about epigenetic mechanisms of DNA methylation and histone modification constrain mutation. Once again you simply have no idea what your talking about."
Of course it does. No gene expression, no 'selection'. Genes are either silenced or promoted, mutation included. There are heritable changes that are passed on. Do you think that stressed bacteria turn on hypermutation across their whole genome? No way. They only 'shuffle' genetic information in certain areas where they may get a sub-optimal, but viable, alternative.