Engineered wood is great stuff, as long as you are absolutely, positively sure it will never be in a wet location. Once it is in a wet location, all bets are off.
So if you are doing interior work and you have a fair amount of confidence that the roof won’t have a chronic leak and you will not have any long-term plumbing problems, it is great stuff. Solid and stable and better than lumber, IMHO. But I had a 12x24 glue-lam beam that wound up under a small leak where I work, and the entire thing delaminated over time. By the time we detected the leak because of the deformation, it was too late, and the entire beam had to be replaced, which was a tricky process, to say the least.
I always assume that EVERYTHING leaks! That way I'm never disappointed, only pleasantly surprised.
One of the big plusses of designing our own place (we did it once before) is that we can put our heads together with the architect and do sensible planning for HVAC and plumbing. E.g., our old house had one wet wall, the kitchen and the bath were back-to-back, and we left the sheetrock off that wall in the laundry room down in the basement.
This was very handy when the contractor left the water on during a hard freeze before we moved in . . . . very easy to fix!
So it's not good for homes located in areas with a high probability of category 3 and above hurricanes. Even a good roof might get some leaks in storm like that.