I can't see any discussion there of how the hemophilia itself became a factor in the downfall of the Spanish as the poster above suggested.
I know how it was a factor with the Russians (because it caused the queen to lean on Rasputin with his supposed healing powers which caused great disgust among the Russians in general) but have not seen how it may have caused the Spanish monarchy to collapse.
Of course, it didn’t have any effect on the fall of the Spanish monarchy, just the personal effect on the lives of the royal family members.