Considering our Founding Fathers put a provision in the Constitution for contracting warships from citizens (Letters of Marque), I don't see that they did draw a line. Warships were the most powerful weapons of their day.
That said, I do think there is a legitimate concern for the regulation of NBC (Nuclear, Biological and Chemical) weapons. These things are inherently unstable and even the government has problems with containment. They should be considered a public hazard, not a weapon protected by the 2nd Amendment.
Nukes are the most powerful, efficient, and strongest deterrent of today’s weapons of war.
Maybe half a suitcase nuke would be good to level a few blocks if ground absolutely must be conceded.