Decades worth of Bureau of Engraving and Printing process, since 1929, has been built upon the fact that bills are 6.14 × 2.61 inches, and a full sheet of paper from Crane & Company is 20.88 x 24.56 inches. I think it'd be a much bigger deal than one might think at first.
they could always move that holographic number which is a bit of a bump to different parts of the bill.
I hope they do appeal this.