The quotation is not strictly accurate, The Roman Caesar Nero, "married" a castratie by taking the role of the husband in one of his unions and in a later "marriage" took the effeminate role. Roman society in his day also had child prostitution, open incest, bestiality, gladiator contests, entertainment consisting of watching people being burned or tortured to dead or killed and eaten by animals etc. Christians and Jews were especially the objects of this barbarism.
Self indulgent depravity is not compassion.
I suspect the founding fathers, who were well versed in classical history, if they had this in mind at all, wrote the constitution with a view to preventing it, as you point out.
"Show me just what Mohammed brought that was new, and there you will find things only evil and inhuman, such as his command to spread by the sword the faith he preached." - Manuel II Palelologus