I'm not extremely fond of Lowe's either - they seem to lean towards items with visual appeal compared to HD. Neither is a great provider of straight 2X4's, though I've had better luck at the local HD when buying wood.
I wish that they'd stick to building supplies & hardware and leave the fluff to Sears, Penneys, and WalMart.
I've worked in both of them and really the only difference is that Home Depot targets the contractor and Lowe's the consumer. Which is why Lowe's looks cleaner with wider aisles and not as much clutter. As for personnel, I won't deal with that as it is different from store to store, so don't flame me on that please!!