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To: Mrs. Don-o

I believe cross-species estrogens and hormones can also be a problem. The drug Premarin has warnings about taking it during pregnancy. However, Premarin is completely natural,coming from pregnant mares. One estrogen in particular, is not found in the human metabolic pathway, that estrogen being estrone. Estrone is a very potent estrogen.

The reason, estrone and some of the other estrogens, in Premarin may be a problem for the fetus, is they do not bind to the human alpha fetal proteins. The fetal alpha proteins do bind to the maternal estrogens, preventing them from having deleterious effects on the fetus. I believe the exogenous hormones may well suppress the development of the pituitary and the hypothalamus, during gestationl. That would explain atypical sexual development.

This would apply to both natural (cross-species) and synthetic estrogens. Other chemicals that are of concern are progesterones, some of them will act as potent androgen blockers. Example: Cyproterone acetate, which is used as treatment for female hirsutism in europe. It is known to cause deformities in genital development in the fetus. It is also known to influence the sexual behavior of rats, when administered at the right period during gestation in rats. Presumably, it would also affect the sexual behavior in human males, making their behavior more feminine.

Other androgen blockers of concer would be finasteride, and similar drugs used to treat male pattern baldness.

Now, testosterone exposure to the fetus will tend to masculinize girl fetuses. Sometimes, the testoterone comes from the fetus itself. In the condition,known as Congenital Adrenal Hyperplasia, there is a metabolic error that does not allow the adrenal gland to convert testosterone into cortisol. The end result is testosterone accumulates in the fetus, producing masculinization of the genitals and masculinizaiton of behavior patterns.


27 posted on 04/22/2008 6:12:24 PM PDT by punster
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To: punster

Correction regarding estrogens in Premarin. After I posted, I remembered the estrogen unique to horses is equilin, instead of estrone.


28 posted on 04/22/2008 8:42:12 PM PDT by punster
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To: punster
Thank you for this detailed information.

It seems to me (a non-expert) that the prenatal development of normal sexual anatomy and physiology is a multiplex and delicate process, and affects, of course, the whole prenatal person, including brain development as well as sexual morphology.

If I were pregnant, I almost think I'd want to grow my own veggies and rise my own chickens in the backyard, drink distilled water, and generally avoid all the hormone disruptors, xenoestrogens and related crap.

I do wish people would "turn the clock forward," stop using contraceptives that were deliberately designed to disrupt normal hormonal physiology, and practice state-of-the-art, 21st Century birth control as the best way to do NFP.

29 posted on 04/23/2008 7:45:17 AM PDT by Mrs. Don-o (Mammalia Primatia Hominidae Homo sapiens. Still working on the "sapiens" part.)
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