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Full results of a failed trial on Vytorin, a medicine taken by millions of Americans to lower cholesterol, left doctors stunned that the drug did not improve heart disease even though it worked as intended to lower three key risk factors.

No, it didn't. They measured the changes in thickness of sections of the carotid arteries as a surrogate for coronary artery atherosclerosis.

Cardiology conference

Beware of pdf links.

http://content.nejm.org/

There's free open access to the NEJM articles and editorials in question.

1 posted on 03/30/2008 4:21:16 PM PDT by neverdem
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To: neverdem

I’m taking enalapil and zetia which were the separate generic components of another drug whose name I can’t remember.

Can anyone out there make any sense of this article for me?


2 posted on 03/30/2008 4:32:52 PM PDT by wildbill
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To: neverdem

Why should I be afraid of PDF links, especially on a legitimate site?


3 posted on 03/30/2008 4:34:18 PM PDT by DB
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To: neverdem

Those with very high cholesterol should use guar gum, which is a common food additive. It is a water soluble fiber with the odd ability to bind with bile. A major component of bile is cholesterol.

A 50/50 mix with non-water soluble fiber, like Metamucil psyllium, or just psyllium husks, combines with the guar gum so that a whole bunch of bile is flushed out of the system.

There is an additional benefit in that the body recycles bile for re-use, but the bile tends to build up contaminants like metals, that it is not bad to get rid of as well.

Taking a guar gum/Metamucil mix twice a week for a month might drop a sky high cholesterol down into the normal range.

It would seem to be a better methodology than using statins, which alter the normal body processes, in that it just uses natural body processes.

They used to sell guar gum powder in health food stores, but it is now only available by mail order.

Insert here the typical caution about taking any kind of medical advice off the Internet. Guar gum is a nutritional supplement, not a medicine.


4 posted on 03/30/2008 4:37:39 PM PDT by yefragetuwrabrumuy
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To: neverdem
It seems as though the medical profession doesn't know whether it's coming or going with respect to cholesterol. One school of thought believes cholesterol is the culprit and it should not be above 180.

The other school of thought is cholesterol by itself is not the problem. It will flow through the arteries without a problem until an amino acid called homcysteine reaches excessive levels. It then acts as a corrosive on the artery walls causing pits in ridges. The cholesterol then collects in the pits and ridges blocking blood flow. This same thinking believes cholesterol under 200 can cause massive deadly strokes. The best antidotes to keep homocystiene levels reasonable is red meat, B6 and B12.
5 posted on 03/30/2008 4:41:34 PM PDT by Man50D (Fair Tax, you earn it, you keep it!)
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To: neverdem

I still feel that a high HDL is much more beneficial than a low LDL. In my family all the males have a high total cholesterol but we also all have a very high HDL. I’m 44, my father 68, and my grandfather is 98. All of us have been told by our doctors that we should be on cholesterol medicines. None of us are, and none of us has ever had heart problems.


7 posted on 03/30/2008 4:45:33 PM PDT by WackySam
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To: neverdem
Before Vytorin - using Zocor
LDL 38, HDL 35, Total Cholesterol 147
Since using Vytorin
LDL,35, HDL 40, Total Cholesterol 115

OMG! What to do, what to do?

8 posted on 03/30/2008 4:50:20 PM PDT by Don Carlos (,)
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To: nnn0jeh

ping


11 posted on 03/30/2008 4:58:52 PM PDT by kalee (The offenses we give, we write in the dust; Those we take, we write in marble. JHuett)
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To: neverdem
There were a lot of emergency "corrective" surgeries for "organ displacement" shortly following the invention of the fluoroscope.

100 years from now they will look back, and snicker we'd been better off with leeches!

12 posted on 03/30/2008 5:14:16 PM PDT by rawcatslyentist (If you're not following Jesus, guess where you're headed?)
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To: neverdem

Doctors practice medicine, ie they put their faith in drugs. I hope someday they will learn how to help promote health via more natural means, and will learn to look at the big picture rather than just lab numbers.


15 posted on 03/30/2008 5:21:06 PM PDT by Abigail Adams
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To: neverdem

A very good friend who knew a lot about medical research told me the studies that linked cholsesterol and hardening of the arteries were not authoratative, the medical profession ran with them anyway. He thought it was mostly genetic that many people can eat/ have high cholesterol and never have hardening of the arteries/ heart disease. However, cholesterol might still be a contributing factor to those predisposed to those conditions.


17 posted on 03/30/2008 5:27:32 PM PDT by Williams
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To: neverdem

bttt


19 posted on 03/30/2008 5:41:07 PM PDT by Peace Is Coming
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To: neverdem

Strange article. I too wonder if the two Vytorin components taken separately work. We are told that the drug did great at accomplishing its risk factor reduction. Why blame the drug if the problem lies with faulty cause and effect analysis on the disease itself?


28 posted on 03/30/2008 6:16:54 PM PDT by NonValueAdded (Who Would Montgomery Brewster Choose?)
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To: miele man

bump


33 posted on 03/30/2008 6:53:44 PM PDT by miele man (Continually voting against iodine deficient libs for 42 years)
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To: neverdem

High cholesterol is over-rated as a problem. As usual the US medical and drug manufacturers are far more worried about altering symptoms then they are about fixing the real problem. Proper diet and exercise is far more healthier than the drugs that get prescribed.


38 posted on 03/30/2008 7:24:05 PM PDT by Always Right (Was it over when the Germans bombed Pearl Harbor?)
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To: neverdem
All that is needed by most people is a proper balanced diet and exercise. I know some need meds, but not in the numbers being prescribed...
39 posted on 03/30/2008 7:24:39 PM PDT by Grizzled Bear ("Does not play well with others.")
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