I don't know about "pesky," but we are "not under the law, but under grace." The Ten Commandments are part of the Mosaic Law, which no longer applies to us as law per se. No, murder and adultery (etc.) are not acceptable, but it's not because of the Mosaic Law; it's because they're contrary to the "law of love."
On the other hand, Christians have no "legal" obligation to keep a sabbath in the Old Testament sense. Periods of rest are a good idea; the commandment sprang from a valid principle, and we're designed so that we function better with periodic rest. But we have no obligation to refrain from work every week from Friday sundown to Saturday sundown, or any other specific day or time.
And don’t forget the “three sheets” dream. It had a double meaning. Christians cannot murder (or violate any of the other nine commandments) with a clean conscience, but we can enjoy pork and lobster.