[Mase]

It's unfortunate we can't (at least I can't) get into the meat of the research. I suspect that if I could I'd find a lot of flaws with these studies. This is not untypical in an environment where research isn't done to find the truth but is, instead, done to achieve the desired results and obtain grant money.

It would be interesting to learn more about how one gets a migraine from a compound that isn't digested. Feeding a lab animal sucralose in quantities that don't relate to real world human consumption is also an issue. Bottom line, if there was any real relationship between sucralose and increased weights in vital organs the FDA would pull it immediately. This, along with aspartame and olestra are the most tested food ingredients in history.

As a comparison, I've seen a clinical study published in the New England Journal of Medicine where a large group of people who were convinced that aspartame was responsible for giving them headaches were brought together for a test. Half the group was given a large amount of aspartame and half were given a placebo. The results showed that 35 percent of the subjects had headaches after taking aspartame, compared with 45 percent who had headaches after taking the placebo.

In one study published in the Journal of Allergy and Clinical Immunology, subjects who believed they were allergic to aspartame received up to 2,000 milligrams of aspartame, the amount contained in about 12 cans of diet soft drink. Not one of the subjects had an allergic reaction after receiving aspartame.

Results of a multicenter, randomized, double-blind, placebo-controlled, crossover study published in a later issue of the JACI, demonstrate that aspartame is no more likely than the placebo to cause urticaria (hives) or angioedema (swelling).

FWIW

[neverdem]

It's unfortunate we can't (at least I can't) get into the meat of the research. I suspect that if I could I'd find a lot of flaws with these studies. This is not untypical in an environment where research isn't done to find the truth but is, instead, done to achieve the desired results and obtain grant money.

Fructose, insulin resistance, and metabolic dyslipidemia

That's an interesting review article with 123 references.

It would be interesting to learn more about how one gets a migraine from a compound that isn't digested.

That's besides the point for those who get migraines from sucralose.

Feeding a lab animal sucralose in quantities that don't relate to real world human consumption is also an issue.

Whether right or wrong, it has become a testing standard for to screen carcinogenicity and teratogenicity.

As a comparison, I've seen a clinical study published in the New England Journal of Medicine where a large group of people who were convinced that aspartame was responsible for giving them headaches were brought together for a test. Half the group was given a large amount of aspartame and half were given a placebo. The results showed that 35 percent of the subjects had headaches after taking aspartame, compared with 45 percent who had headaches after taking the placebo.

It's called the placebo effect for a reason.

In one study published in the Journal of Allergy and Clinical Immunology, subjects who believed they were allergic to aspartame received up to 2,000 milligrams of aspartame, the amount contained in about 12 cans of diet soft drink. Not one of the subjects had an allergic reaction after receiving aspartame.

Results of a multicenter, randomized, double-blind, placebo-controlled, crossover study published in a later issue of the JACI, demonstrate that aspartame is no more likely than the placebo to cause urticaria (hives) or angioedema (swelling).

Allergic reactions are often idiosyncratic much like sucralose induced migraines. A headache is a symptom. Urticaria or angioedema are physical signs of an acute reaction, often allergic.