Thanks for posting this article, blam.
It’s the first I’m hearing of vitamin D receptor (VDR), I’d not heard before that VitD might be harmful instead of helpful.
HIGHLIGHT for myself:
‘The paper explains how the Vitamin D Nuclear Receptor (VDR) acts in the repression or transcription of hundreds of genes, including genes associated with diseases ranging from cancers to multiple sclerosis.
‘”The VDR is at the heart of innate immunity, being responsible for expression of most of the antimicrobial peptides, which are the body’s ultimate response to infection,” Marshall said.’
More highlighting (no pun intended):
“Molecular biology is now forcing us to re-think the idea that a low measured value of vitamin D means we simply must add more to our diet. Supplemental vitamin D has been used for decades, and yet the epidemics of chronic disease, such as heart disease and obesity, are just getting worse.”
“Our disease model has shown us why low levels of vitamin D are observed in association with major and chronic illness,” Marshall added. “Vitamin D is a secosteroid hormone, and the body regulates the production of all it needs. In fact, the use of supplements can be harmful, because they suppress the immune system so that the body cannot fight disease and infection effectively.”
Marshall’s research has demonstrated how ingested vitamin D can actually block VDR activation, the opposite effect to that of Sunshine. Instead of a positive effect on gene expression, Marshall reported that his own work, as well as the work of others, shows that quite nominal doses of ingested vitamin D can suppress the proper operation of the immune system. It is a different metabolite, a secosteroid hormone called 1,25-dihydroxyvitamin D, which activates the VDR to regulate the expression of the genes. Under conditions that exist in infection or inflammation, the body automatically regulates its production of all the vitamin D metabolites, including 25-hydroxyvitamin D, the metabolite which is usually measured to indicate vitamin D status.
Vitamin D deficiency, long interpreted as a cause of disease, is more likely the result of the disease process, and increasing intake of vitamin D often makes the disease worse. “Dysregulation of vitamin D has been observed in many chronic diseases, including many thought to be autoimmune,” said J.C. Waterhouse, Ph.D., lead author of a book chapter on vitamin D and chronic disease.
“We have found that vitamin D supplementation, even at levels many consider desirable, interferes with recovery in these patients.”
“We need to discard the notion that vitamin D affects a disease state in a simple way,” Marshall said.
Hi Quix, Hi Starwise,
This is the article where folks are warned to not use Vitamin D.
It says in there that l-form bacteria which cause or worsen auto-immune diseases get stronger if there’s more VitD in the body. So, folks with some diseases should NOT take VitD.
On this thread, I posted some of my notes from the reading, I think starting at Post #62, for anyone who is interested.
There’s some protocol ... I’ll look back and get the name of it and post it in a minute ... where folks with autoimmune disease actually avoid sunlight and other forms of light for two years to try to kill off the l-form bacteria in their bodies.
Give me a minute.
{Qx, thanks for the heads up.}