[JohnBovenmyer]

There are lots of folks on this subcutaneously for RA, fewer but still alot, on it for psoriasis that way and probably collectively a lot across several other indications. It’s pricey used the usual way. But if this is given via a spinal to acheive levels in just the CSF rather than the whole body I’d expect the dose required to be much less and thus the price lower.

[JohnBovenmyer]

I just checked out the article, but couldn’t find the commentary on it listed there. It’s not intrathecal but rather extrathecal hoping for delivery via paraspinal vessels. And it uses the standard 25 mg weekly dose schedule so would cost the same as RA treatment plus some charge for the skilled person required to inject it that way weekly. Drug costs ~$15k/year still might be paid for if it kept patients out of nursing homes. Sounds like a great excuse for further studies to optimize the dosing and results and also to compare other routes of delivery (does it have to be paraspinal or would subcutaneous also work) and the other TNF blockers. And also to collect data on the possible risk of demyelinating disorders from this usage.

[fightinJAG]

The drug price will probably be lower, as you said, but the procedure price will be much higher. Probably have to be done in an outpatient center. You’ll have to pay the person who does the spinal infusion and whatever lab tests they do before and after each treatment.

It won’t be a self-injected drug like it is now for this use!