“Histones are a group of highly evolutionarily conserved proteins that play a critical role in the proper packaging of DNA within the eukaryotic nucleus. DNA (~146 bp) along with the histones (two each of histones H2A, H2B, H3 and H4) form the fundamental repeating subunit of chromatin, known as the nucleosome (Figure 1). Since the human genome is composed of around three billion bases of DNA (3,000,000,000 bp), it is likely that there are tens of millions of nucleosomes within a single human nucleus. Because of their tight association with DNA, it has long been postulated that the histones directly participate in many different DNA-templated programs including transcription, replication, recombination and DNA repair. But there is a conundrum: if each tiny histone protein contains the same exact amino acid sequence as the other millions of histones in the nucleus, how could they possibly direct distinct and, sometimes, opposing nuclear processes (i.e. transcriptional activation versus inactivation)? One possible answer to this question has gained widespread acceptance within the last decade – the histone code.”
Again, Allmendream’s argument is not with us, but with his fellow evolutionary scientists. If Allmendream is saying that somehow the DNA/Universal Code directs the myriad of functions of millions and millions of histones all by its lonesome, then the burden is on Allmendream to show how the DNA/Universal Code accomplishes this incredible feat. Let me underscore this point. Just describing what happens won’t cut it. He needs to specify HOW the DNA/Universal Code directs the “distinct and, sometimes, opposing nuclear processes” of the histone proteins. That means, Allmendream needs to translate the specific portions of the Universal Code such that he can explain the specific actions and functions of histone proteins. If Allmendream cannot do this, then his insistence that there is only one code operating is pure conjecture. Do computers operate on single code? No, they operate on many codes (ie binary, windows, word, etc)...in other words computers have codes upon codes upon codes. And computers are no match for the sophistication of the nuclear processes of even a single cell.
Let's hear it from Mr. Computer Science.
Are you suggesting that the executables of programs like Word are distributed in some form other than binary machine code?
There are, of course, script languages, but CPUs do not read scripts except as a byproduct of executing a script interpreter.
He was saying this, and I wasn't disputing it...am I missing something?
Still, even though the histones find their origins in the wider genome...they become coding agents, conveying information from one portion of the genome, to another. Hence the code-within-code type of thinking that arrangement gives rise to. That's all I was trying to say...
I pinged you to this discussion, since he mentioned you in his last post to me. So now, I address this to him also.
OK. What part of this is not done by the Universal genetic code?
There are genes for histones. These are transcribed by RNA polymerase and translated into histone proteins at the ribosome according the the Universal Genetic Code; then the histone can go bind DNA and do its job.
There are genes for DNA methylase. These are transcribed into mRNA then translated into proteins (according to the Universal Genetic Code)these proteins can then bind to DNA and methylate it; increasing the affinity of the DNA for binding histones.
Histones can be Acetylated making them more or less able to bind DNA. These Histone Acetyl Transferases (HAT’s) and Histone De-Acetyl Transferases (HDAC’s) are proteins coded for by the genetic code that then interact with histones and modulate its ability to interact with DNA.
RNA polymerase can be phosphorylated by proteins coded for by the universal genetic code, this in turn effects which promoter regions of which genes it will preferentially interact with.
ARE YOU BEGINNING TO GET THE PICTURE GGG? IT IS ALL DONE BY THE UNIVERSAL GENETIC CODE. THE UNIVERSAL GENETIC CODE CAN BE TRANSLATED, EVERYTHING ELSE IS A CONTROL MECHANISM. IF ANYONE OF THESE THINGS IS AN ACTUAL CODE PLEASE TRANSLATE IT FOR ME. YOU CANNOT! WHAT INFORMATION DOES THIS “CODE” CONVEY OTHER THAN ON/OFF OR THIS/NOT THAT?