[BlueDragon]

Thank you for the ping. It's always good to hear from you. I don't always get back to you on this or that ping, but I always do, eventually if not sooner, read the article, follow the thread, etc.

Let's see...how did it go? From previous info; proteins could vary somewhat, depending on what other neighboring alleles were present, or not? Something like that.

It's as if there are codes, within the code? As opposed to being simply "here's the gene that makes this protein" [with no variation, period].

[GodGunsGuts]

I just wonder how many codes we will find as we go forward. Codes upon codes upon codes...We truly are fearfully and WONDERFULLY made!

[allmendream]

Actually your statement is absolutely incorrect. Histone affinity is a function of methylation of DNA. Thus methylation of DNA leads to higher affinity for Histones making the gene in question, and being bound to Histones makes transcribing the gene into a message capable of being made into a protein more difficult, thus turning ‘off’ the gene.

The gene, when turned on, will still make the same protein, according the the Universal Genetic Code (AUG = Methionine, etc). This paper is saying that post translational (after it was made from RNA) modifications of histone proteins can lead to some sections of DNA being preferentially turned on or off.

The code is still the code. This is all about on or off. The gene still makes the same protein.