I have the feeling that if the Huckster had been around in 1919, he would be championing the 18th Amendment...
Smoking and drinking however, while destructive to the individual, cannot be regulated at the federal level in a constitutionally kosher way. If a predominantly Baptist county in Texas - or LDS county in Utah - wants to remain "dry", that's one thing and is federalism at its finest. But federal statute!? No. Not for this.