Just wash your hands afterwards, for heaven's sake! (I mean, what is all the fuss about? It's just guts. We all have them.)
Gloves do get in the way, but if you are doing many at a time, it’s that or badly chapped hands. I boned out and packaged 7 deer in six days a couple weeks ago with gloves and a wrist brace. Lot of work but the meat can’t be beat!