As an aside (so many here so knowledgeable) my husband has terrible problems with neuropathy in his lower and legs feet (it was pain and clumsiness that lead him to the doc in in the first place). Anybody taking any wonder drug that helps? When it acts up, he is literally up all night.
Don't panic. Actos works differently than Avandia and is so far not targeted for any action.
As for the neuropathy....his doc needs to assist. If there has been extensive nerve damage before he started getting treatment then it may be a problem for some time. So many variables. I have been on Actos and Metformin for some time but through diet and exercise have been able to get off of Glyburide (which whips the pancreas to produce more insulin) which can, over time, have a bad effect on the islet cells in the pancreas...making things worse.
That was one of my goals...to get off that drug.
There is a new product on the market that I have seen ads for that will combat the pain and burning in the legs and feet due to Type II...I don't recall the name but it is being advertised on TV these days.
If I find it I'll ping you.
Benfotiamine may help your husband. It’s kept my type 1 diabetic son healthy so far!
We found out this year that many in my family have BeriBeri (thiamine or B1 deficiency) and we're now taking B1 shots.
The symptoms of BeriBeri are the same as the complications of diabetes. Benfotiamine is a synthetic B1 and is harder for the body to eliminate. It would seem that that's why it helps.
I am not a diabetic, but I've had idiopathic neuropathy for years. (We now know that it's from the B1 deficiency.) My neuropathy has improved ten-fold since I've started the shots. I do have some permanent nerve damage, but it's livable.
If I were in your shoes, I'd start my husband on Benfo right away. It can't hurt and has a good chance of helping. (I get mine from benfotiame.net) I've just started taking it myself.