What is your personal opinion about the right of self-defense? Do you think it should be prohbited, and how do you think the framers would respond to that today?
Self-defense is an inalienable right -- part of a right to life. Because of that, it cannot be taken away without individual due process.
The protection of your right to self-defense with a weapon, on the other hand, is up to the citizens of each state. The citizens decide which weapons may be used and under what conditions.
"and how do you think the framers would respond to that today?"
The framers would support a decision made at the state level -- that is the sum and substance of federalism.