Some of my favorites
Bus I-85 from Greensboro NC to Lexington NC is the old highway. Lots of old motels
360 from Roanoke Va to Richmond Va. Classic old highway.
US 29 from Greensboro north
US 17 along the NC coast
“US 17 along the NC coast”
17 is nice further south too. The ol’ Atlantic Coast Highway
If you get the opportunity to drive US 27 from Tallahassee (I-10) south to Tampa, I say do it. This is an old part of Florida that most people have no clue exists even many that live in Florida.
“360 from Roanoke Va to Richmond Va. Classic old highway.”
I think you mean 460. I’ve driven it a lot. 360 goes from Danville to Richmond.
You an also find a lot of America along the original pieces of U.S. 11 that are left.