In general? It doesn't. Now if you want to get into specifics, then maybe I could answer your question.
"Since these people are not being imprisoned for harming others, but for choosing a lifestyle many find disagreeable."
Disagreeable. I like that. Kinda like "harmless weed".
There are many who say drug use harms the user and those around them. So I think it goes beyond disagreeable.
"And if you look like people like Karen Tandy and John Walters, they are actively trying to suppress any speech that would be pro-legalization like they did in Montana."
Suppressing speech? How about "telling the other side"?
"The same complaint was filed in Nevada two years ago against John Walters .... Nevada officials decided a few months later not to take action against Walters because he was carrying out the duties of his office, which include combatting marijuana legalization efforts. They cited an 1890 U.S. Supreme Court decision that federal officials are immune from state action when exercising the functions of their offices."