OK - I’m stumped. Which sitcom? Got a link to the script?
At the end of the show there's a quick outtake where the daughter gives the clueless mom a shirt as a present that says "Shemale" across the front of it. The mom says "Thank you, darling" and the daughter excitedly says " It's a Shemale' ", pronouncing "Shemale" like "Channel" or "sha-mall-EE".