Not the same comparison at all.These things are large and can be seen with satellites from space. A strike package would fly out of is range and deliver a salvo of standoff weapons. Boom no more air defense.Yes its mobile but it is still large.
Sure.
But not all you can see you can hit.
Also theese things are stationed some 100 km inside Russian terrtitory, with range of 400 km (lets say 200 miles) it is hard to get them in range of your onboard missiles. Also S-300/400 are protected by Tor or Tunguska systems.
And that is if you get to see lounchers.
And if you are left with usable satelites to see them at first place.
Cypruss is using S-300 missiles to defend against Turkey.