A Kimber 45 is a fine choice. It will hold its value well. I currently own a Glock 21 in 45. It is a simpler design and has the 13+1 capacity.
I also have a G21, a very soft shooting .45 and extremely accurate.
This year, supposedly in the earlier part of it, Glock will be releasing their slimmer framed G21 called the G21SF. This model will have a reduced grip dimension which will appeal to shooters with smaller hands (a frequent concern to those who have held the current model). Also new to this pistol will be an ambidextrous magazine release and the option of a 1913 style picatinny rail for more weapon-light mounting options.
This leads me into also recommending that the purchaser of any firearm for home defense seriously consider the purchase of a high quality weapon-light and/or handheld to more clearly identify their potential target. Output of 60 lumens or more is ideal for this task, along with a momentary or constant-on switch option. Surefire, Streamlight, Pentagon, and other quality manufacturers are worth checking out.