Home defense? Shot occasionally?
Get a revolver! pretty much foolproof.
Semi Autos are ok if you practice enough have the controls become second nature.
In the heat of a possible break-in your having to think about what control to push, flip, whatever goes out the window.
4" .357 Smith or Ruger. Load with .38+P ammo. (.357 in a house will deafen you w/o ear protection)
-ping