The article indicates that they went well beyond Glendale to Roseburg, Oregon. At least Google Earth indicates that getting from there to Gold Beach, where they had a room for the night, would have taken them on state Highway 42. They only switched to searching that road sometime on Saturday. It's a twisty mountain road with lots of opportunities to get lost.
Prayers are required, but hope is still not unreasonable.
Google maps says that Glendale is south of Roseburg, near Wolf Creek.
http://www.google.com/maps?f=q&hl=en&q=glendale,+or&ie=UTF8&om=1&z=12&ll=42.759869,-123.428307&spn=0.112927,0.346069&iwloc=addr